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When Actos is taken with other prescription drugs, over-the-counter medications, vitamins, and supplements, it may change how they work or increase the frequency or severity of side effects. Pioglitazone Hcl or Actos Savings, Coupons and Information. | PIOGLITAZONE (pye oh GLI ta zone) treats type 2 diabetes. It helps your body use insulin effectively, which decreases your blood sugar (glucose). Compare Actos prices, print discount coupons, find manufacturer promotions, copay cards and patient assistance programs. Actos prices and discounts | AARP Prescription Discounts This drug may cause or make heart failure worse. Tell your doctor if you have had heart failure. Do not take this drug if you have moderate to severe heart failure or any signs of heart failure. You will be watched closely while starting this drug and if your dose is raised. 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